Dosage & Administration
Tablets:
Initial:
2 tablets twice a day
Maintenance:
1 tablet twice a day

Liniment:
Apply 2 to 4 times a day on affected area

Presentation
Tablets:
30 Tablets Blister / bottle
Liniment:
100 ml & 60 ml bottle

Composition
Tablets
Each Arth-BRM tablet contains:
Ashwagandha (Withania somnifera) 100 mg
Triphala (T. chebula, T. Belerica,
E. Officinalis)
100 mg
Extracts (Ghanas) of
Saunth (Zingiber officinale) 50 mg
Sallaki (Boswellia serrata) 100 mg
Haldi (Curcuma longa) 100 mg
References
1. H. Ichikawa, Y. Takada, S. Shishodia, B. Jayaprakasam, M.G. Nair, B.B. Aggarwal. Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-kappaB (NF-kappaB) activation and NF-kappaB-regulated gene expression. Mol Cancer Ther, 5 (2006), pp. 1434–1445
2. V.H. Begum, J. Sadique. Long term effect of herbal drug Withania somnifera on adjuvant induced arthritis in rats. Indian J Exp Biol, 26 (1988), pp. 877–882
3. M. Rasool, P. Varalakshmi. Suppressive effect of Withania somnifera root powder on experimental gouty arthritis: an in vivo and in vitro study. Chem Biol Interact, 164 (2006), pp. 174–180.
4. Khanna D, Sethi G, Ahn KS, Pandey MK, Kunnumakkara AB, Sung B, Aggarwal A, Aggarwal BB. Natural products as a gold mine for arthritis treatment. Curr Opin Pharmacol. 2007 Jun;7(3):344-51.
5. Singh S, Aggarwal BB: Activation of transcription factor NFkappa B is suppressed by curcumin (diferuloylmethane). J Biol Chem 1995, 270:24995-25000.
6. Shishodia S, Amin HM, Lai R, Aggarwal BB: Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma. Biochem Pharmacol 2005, 70:700-713.
7. Kumar A, Dhawan S, Hardegen NJ, Aggarwal BB: Curcumin (diferuloylmethane) inhibition of tumor necrosis factor (TNF)- mediated adhesion of monocytes to endothelial cells bysuppression of cell surface expression of adhesion molecules and of nuclear factor-kappaB activation. Biochem Pharmacol 1998, 55:775-783.
8. Aggarwal S, Ichikawa H, Takada Y, Sandur SK, Shishodia S, Aggarwal BB: Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation. Mol Pharmacol 2006, 69:195-206.
9. Skrzypczak-Jankun E, Zhou K, McCabe NP, Selman SH, Jankun J: Structure of curcumin in complex with lipoxygenase and its significance in cancer. Int J Mol Med 2003, 12:17-24.
10. Aggarwal BB, Kumar A, Bharti AC: Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res 2003, 23:363-398.
11. Onodera S, Kaneda K, Mizue Y, Koyama Y, Fujinaga M, Nishihira J: Macrophage migration inhibitory factor up-regulates expression of matrix metalloproteinases in synovial fibroblasts of rheumatoid arthritis. J Biol Chem 2000, 275:444-450.
12. Liacini A, Sylvester J, Li WQ, Huang W, Dehnade F, Ahmad M, Zafarullah M: Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes. Exp Cell Res 2003, 288:208-217.
13. Jackson JK, Higo T, Hunter WL, Burt HM: The antioxidants curcumin and quercetin inhibit inflammatory processes associated with arthritis. Inflamm Res 2006, 55:168-175.
14. Lev-Ari S, Strier L, Kazanov D, Elkayam O, Lichtenberg D, Caspi D, Arber N: Curcumin synergistically potentiates the growth inhibitory and pro-apoptotic effects of celecoxib in osteoarthritis synovial adherent cells. Rheumatology (Oxford) 2006, 45:171-177.
15. Shakibaei M, John T, Schulze-Tanzil G, Lehmann I, Mobasheri A: Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis. Biochem Pharmacol 2007, in press.
16. Joe B, Rao UJSP, Lokesh BR: Presence of an acidic glycoprotein in the serum of arthritic rats: modulation by capsaicin and curcumin. Mol Cell Biochem 1997, 169:125-134.
17. Funk JL, Oyarzo JN, Frye JB, Chen G, Lantz RC, Jolad SD, Solyom AM, Timmermann BN: Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis. J Nat Prod 2006, 69:351-355.
18. Reddy GK, Dhar SC: Effect of a new non-steroidal anti-inflammatory agent on lysosomal stability in adjuvant induced arthritis. Ital J Biochem 1987, 36:205-217.
19. Sharma ML, Bani S, Singh GB: Anti-arthritic activity of boswellic acids in bovine serum albumin (BSA)-induced arthritis. Int J Immunopharmacol 1989, 11:647-652.
20. Kimmatkar N, Thawani V, Hingorani L, Khiyani R: Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee–a randomized double blind placebo controlled trial. Phytomedicine 2003, 10:3-7.
21. Takada Y, Ichikawa H, Badmaev V, Aggarwal BB: Acetyl-11-ketobeta-boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-kappa B and NF-kappa B-regulated gene expression. J Immunol 2006, 176:3127-3140.
22. Safayhi H, Sailer ER, Ammon HP: Mechanism of 5-lipoxygenase inhibition by acetyl-11-keto-beta-boswellic acid. Mol Pharmacol 1995, 47:1212-1216.
23. Sharma RK, Dash B. Carka Samhita Volume II. Varanasi, India: Chowkamba Sanskrit Series Office, 1998.
24. Kaviratna AC, Sharma P. Caraka Samhita, Vols. 1–4. Delhi, India: Sri Satguru Publications, 1996.
25. Rastogi RP, Mehrotra BN. Compendium of Indian Medicinal Plants, Vol. 1–3. New Delhi, India: Publications and Information Directorate, 1993.
26. Rasool M, Sabina EP. Anti-inflammatory effect of the Indian Ayurvedic herbal formulation triphala on adjuvant-induced arthritis in mice. Phytother Res 2007;21:889–894.
27. Sabina EP, Rasool M. An in vivo and in vitro potential of Indian ayurvedic herbal formulation Triphala on experimental gouty arthritis in mice. Vascular Pharmacology 48 (2008) 14–20.
28. Schulick P. Ginger, Common Spice and Wonder Drug. 3rd ed. Brattleboro, VT: Herbal Free Press, Ltd., 1996.
29. Kiuchi F, Iwakami S, Shibuya M, et al. Inhibition of prostaglandin and leukotriene biosynthesis by gingerols and diarylheptanoids. Chem Pharm Bull 1992; 40:387-91.
30. Jana U, Chattopadhayay RN, Shaw BP. Preliminary studies on anti-inflammatory activity of Zingiber officinale Rosc., Vitex negundo Linn. and Tinospora cordifolia (Willid) miers in albino rats. Indian J Pharmacol 1999;31:232-3.
31. Altman RD, Marcussen KC. Effects of a ginger extract on knee pain in patients with osteoarthritis. Arthritis Rheum 2001; 44:2531-8.
32. Bliddal H, Rosetzsky A, Schlichting P, et al. A randomized, placebocontrolled, cross-over study of ginger extracts and ibuprofen in osteoarthritis. Osteoarthritis Cartilage 2000; 8:9-12.
33. Wigler I, Grotto I, Caspi D, Yaron M: The effects of Zintona EC (a ginger extract) on symptomatic gonarthritis. Osteoarthritis Cartilage 2003; 11:783–789.
Explore Product
Categories
Products
Arth - Brm - Liniment/Tablets
Therapeutic Category : Anti-arthritic Biological Response Modifier
Actions
Boswellic acids & oleoresin from Boswellia serrata, Ellagic acid, gallic acid, chebulinic acid, bellericanin, ß-sitosterol & flavanoids from Triphala, Phenolic gingerols from Zingiber officinale and Curcuminoids from Curcuma longa are the principle active / marker phytochemicals in Arth-BRM tablets. These multiple phytochemicals synergize to “switch-off” inflammatory & degenerative processes in musculoskeletal and synovial microenvironment by acting at numerous aspects of the inflammatory process.

Similarly, the botanicals and volatile oils in Arth-BRM liniment provide instant relief in musco-skeletal conditions due to local analgesic and counter-irritant effects.
Indications
  • Joint pain (Sandhishul)
  • Osteoarthropathy / Musculo-skeletal pain (Sandhigata vata)
  • Stiffness of joints (Sandhigraha)
  • Arthritis (Sandhi sotha)
  • Gout (Vatarakta)
  • Lumbago (Prsthna sula)