Presentation
Tablets :
30 Tablets Blister / bottle
Syrup :
100 ml & 200 ml bottle

Composition
Tablets
Each Detoxina tablet represents :
Kutki (Picrorhiza kurroa) 120 mg
Punarnava (Boerhaavia diffusa) 120 mg
Kalmegh (Andrographis paniculata) 120 mg
Devdangri (Luffa echinata) 60 mg
Bhangro (Eclipta alba) 60 mg
Bhuiavala (Phyllanthus niruri) 60 mg
Syrup
Each 10 ml Detoxina Syrup represents :
Kutki (Picrorhiza kurroa) 50 mg
Punarnava (Boerhaavia diffusa) 50 mg
Devdangri (Luffa echinata) 50 mcg
Jeshtimadh (Glycerrhiza glabra) 100 mcg
Kalmegh (Andrographis paniculata) 200 mg
Bhangro (Eclipta alba) 200 IU
Bhuiavala (Phyllanthus niruri) 200 mg
References
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4. Thyagarajan, S.P., Thiruneelakantan, K., Subramanian, S. and Sundaravelu, T. In vitro inactivation of HBsAg by Eclipla alba Hassk and Phyllanthus niruri Linn. Indian Journal of Medical Research. 1982, 76 (Suppl.), 124- 130.
5. Wagner, H., Geyer, B., Kiso, Y., Hikino, H. and Rao, G.S. Coumestans as the main active principles of the liver drugs Eclipta alba and Wedelia calendulacea. Planta Medica. 1986, 52, 370-374.
6. A.K. Saxena et al. Hepatoprotective effects of Eclipta alba on subcellular levels in rats J. Ethnopharmacol. 1993, 40: 155-161
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8. Vaidya A B et al. Therapeutic potential of Luffa echinata Roxb in viral hepatitis. Ind J Pharmacol. 1976, 8:245
9. Kumar VP et al . Effect of Luffa echinata on lipid peroxidation and free radical scavenging activity.J Pharm Pharmacol. 2000 Jul;52(7):891-4.
10. Thyagarajan SP et al. Invitro inactivation of HBsAg by Eclipta alba Hassk and Phyllanthus niruri Linn. Indian J. Med. Res. 1982; 76 (Suppl.): 124–30.
11. Venkateswaran PS et al. Effect and an extract from Phyllanthus niruri on hepatitis B and woodchuch hepatitis viruses: Invitro and invivo studies. Proc. Natl Acad. Sci. USA 1987; 84: 274–8
12. Rao YS. Experimental production of liver damage and its protection with Phyllanthus niruri and Cappris spinosa in white albino rats. Probe 1985; 3: 117–19.
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14. Jayanthi V, et al. Value of herbal medicines, Phyllanthus niruri, Eclipta alba, Piper Longus, Thippili (Tamil) and combination of Phyllanthus niruri and Ricinus communis (Icterus-Pharm. products) in acute viral hepatitis. J. Gasteroenterol. Hepatol. 1988; 3: 533–4.
15. Geetha J, et al. Efficacy of ‘Essential Phospholipid substance’ of Soya Bean oil and Phyllanthus niruri in acute viral hepatitis. J. Gen. Med. 1992; 4: 53–8.
16. Handa, S.S. and Sharma, A. Hepatoprotective activity of andrographolide from Andrographis paniculala against carbon tetrachloride. Indian J Med Res. 1990 Aug; 92:276-83.
17. Handa, S.S. and Sharma. A. Hepatoprotective activity of andrographolide against galactosamine and paracetamol interaction in rats, Indian J Med Res. 1990 Aug; 92:284-292.
18. Handa. S.S.. et al. Natural products and plants as liver protecting drugs. Fitoterapia, 1986, 57. 307-351.
19. Shukla. B. et al. Choleretic effect of andrographolide in rats and guinea pigs. Planta Medica 1992, 58, 146-149.
20. Kapil A, et al. Antihepatotoxic effects of major diterpenoid constituents of Andrographis paniculata. Biochemical Pharmacology, 1993, Vol. 46. No. 1, pp. 182-185.
21. Lin F.L et al. Antioxidant, Antioedema and Analgesic Activities of Andrographis paniculata Extracts and their Active Constituent Andrographolide. Phytother. Res. 2009
22. Tripathi R et al. Free radical induced damages to rat liver subcellular organelles: Inhibition by Andrographis paniculata extract. Indian Journal of Experimental Biology Vol. 45, November 2007,
pp. 959-967
23. Trivedi, N.P et al. Hepatoprotective Effect of Andrographolide Against Hexachlorocyclohexane-Induced Oxidative Injury. Integr Cancer Ther 2007; 6: 271
24. Singh R.P et al.Modulatory Influence of Andrographis paniculata on Mouse Hepatic and Extrahepatic Carcinogen Metabolizing Enzymes and Antioxidant Status. Phytother. Res. 15, 382–390 (2001)
25. Chang T et al. Modulation of the expression of the p class of glutathione S-transferase by Andrographis paniculata extracts and andrographolide. Food and Chemical Toxicology 2008, 46:1079–1088
26. Dwivedi Y et al. Effects of picroliv, the active principle of Picrorhiza kurroa, on biochemical changes in rat liver poisoned by Amanita phalloides. Chung Kuo Yao Li Hsueh Pao 1992;13:197-200.
27. Floersheim GL, et al. Protection against Amanita phalloides by the iridoid glycoside mixture of Picrorhiza kurroa (kutkin). Agents Actions 1990;29:386-387.
28. Santra A, et al. Prevention of carbon tetrachloride-induced hepatic injury in mice by Picrorhiza kurrooa. Indian J Gastroenterol 1998;17:6-9.
29. Dwivedi Y, et al. Hepatoprotective activity of picroliv against carbon tetrachloride-induced liver damage in rats. Indian J Med Res 1990;92:195-200.
30. Saraswat B, et al. Anticholestatic effect of picroliv, active hepatoprotective principle of Picrorhiza kurrooa, against carbon tetrachloride induced cholestasis. Indian J Exp Biol 1993;31:316- 318.
31. Dwivedi Y, et al. Perfusion with picroliv reverses biochemical changes induced in livers of rats toxicated with galactosamine or thioacetamide. Planta Med 1993;59:418-420.
32. Dwivedi Y, et al. Picroliv and its components kutkoside and picroside I protect liver against galactosamine-induced damage in rats. Pharmacol Toxicol 1992;71:383-387.
33. Visen PK, et al. Prevention of galactosamine-induced hepatic damage by picroliv: study on bile flow and isolated hepatocytes (ex vivo). Planta Med 1993;59:37-41.
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35. Dwivedi Y, et al. Picroliv protects against aflatoxin B1 acute hepatotoxicity in rats. Pharmacol Res 1993;27:189-199.
36. Singh V, et al. Effect of picroliv on low density lipoprotein receptor binding of rat hepatocytes in hepatic damage induced by paracetamol. Indian J Biochem Biophys 1992; 29:428-432.
37. Dwivedi Y, et al. Picroliv affords protection against thioacetamide-induced hepatic damage in rats. Planta Med 1991; 57:25-28.
38. Saraswat B, et al. Protective effect of picroliv, active constituent of Picrorhiza kurrooa, against oxytetracycline induced hepatic damage. Indian J Exp Biol 1997; 35:1302-1305.
39. Dwivedi Y, et al. Picroliv protects against monocrotalineinduced hepatic damage in rats. Pharmacol Res 1991; 23:399-407.
40. Chander R, et al. Picroliv, picroside-I and kutkoside from Picrorhiza kurrooa are scavengers of superoxide anions. Biochem Pharmacol 1992; 44:180-183.
41. Kidd PM. Glutathione: Systemic protectant against oxidative and free radical damage. Altern Med Rev 1997; 2:155-176.
42. Chander R, et al. Effect of picroliv on glutathione metabolism in liver and brain of Mastomys natalensis infected with Plasmodium berghei. Indian J Exp Biol 1992; 30:711-714.
43. Chander R, et al. Picroliv prevents oxidation in serum lipoprotein lipids of Mastomys coucha infected with Plasmodium berghei. Indian J Exp Biol 1998;36:371- 374.
44. Singh V, et al. Effect of picroliv on protein and nucleic acid synthesis. Indian J Exp Biol 1992; 30:68-69.
45. Pandey BL, et al. Immunopharmacological studies on Picrorhiza kurroa Royle-ex-Benth. Part IV: Cellular mechanisms of anti-inflammatory action. Indian J Physiol Pharmacol 1989; 33:28-30.
46. Pandey BL, et al. Immunopharmacological studies on Picrorhiza kurroa Royle-Ex-Benth. Part V: Anti-inflammatory action: relation with cell types involved in inflammation. Indian J Physiol Pharmacol 1988; 32:289-292.
47. Pandey BL, et al. Immunopharmacological studies on Picrorhiza kurroa Royle-ex-Benth. Part III: Adrenergic mechanisms of anti-inflammatory action. Indian J Physiol Pharmacol 1988;32:120-125.
48 Simons JM, et al. Metabolic activation of natural phenols into selective oxidative burst agonists by activated human neutrophils. Free Radic Biol Med 1990;8:251-258.
49 Stolk J, et al. Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol. Am J Respir Cell Mol Biol 1994;11: 95-102.
50 Shukla B, et al. Choleretic effect of picroliv, the hepatoprotective principle of Picrorhiza kurroa. Planta Med 1991;57:29-33.
51 Vaidya AB, et al. Picrorhiza kurroa (Kutaki) Royle ex Benth as a hepatoprotective agent-experimental and clinical studies. J Postgrad Med 1996; 42:105- 108.
52 Mehrotra R, et al. In vitro studies on the effect of certain natural products against hepatitis B virus. Indian J Med Res 1990;92:133-138.
53 Saraf A P Dept. Pharmacology G.M.C. & J.J. Group of Hospitals Hepatoprotective Activity of a Compound Herbal Formulation “Detoxina” In Carbon Tetrachloride Induced Liver Damage. Data on file
54 Saraf A P Dept. Pharmacology G.M.C. & J.J. Group of Hospitals .Enhanced Hepatic Antioxidant Status with a Compound Herbal Formulation “Detoxina” – A Possible Mode of Hepatoprotetive Action. Data on file
55 Waigankar K. Dept. Pharmacology G.M.C. & J.J. Group of Hospitals In the thesis for the degree of M.Phil (Biochemistry).
56 Saraf A P Dept. Pharmacology G.M.C. & J.J. Group of Hospitals .Effect of Detoxina in growth of children – An open labeled comparative study. Data on file
57 Hepatoprotective adjuncts in management of HIV & Tuberculosis
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Categories
Products
Detoxina - Syrup/Tablets
Therapeutic Category : Hepato-protective & Appetite Stimulant
Actions
Individual botanicals in Detoxina tablets & syrup have multiple hepato-tropic actions which help in :
  • Maintaining structural and functional integrity of the liver,
  • Protecting hepatic metabolizing enzymes,
  • Overcoming hepatic inflammation & oedema,
  • Normalising impaired hepatic function and abnormal liver function tests,
  • Stimulating active liver cell proliferation and liver cell regeneration,
  • Correcting impaired hepato-cellular bile production and promotes bile flow,
  • Increasing hepato-cellular antioxidant capacity & hepatic detoxification capacity
  • Improving appetite, digestion and growth.
Botanicals in Detoxina also exhibit specific HBV antiviral activity to :
  • Inactivate HBV viral surface antigen
  • Inhibit HBV replication by inhibiting the viral DNA polymerase
Indications
In cases of
  • Anorexia (Kshudhamandya)
  • Growth failure (Vruddhi viphalata)
  • Chronic indigestion (Ajirna)
  • Convalescence (Rogopasamana)
  • Malnutrition (Kuposhana)
  • Prophylatically with anti-TB drugs
    • Adults : 1 tablet o.i.d. or 15 ml (tablespoonful) once a day
    Children : 10 ml (2 teaspoonfuls) once a day
In cases of
  • Mild to moderate liver dysfunction associated with alcohol consumption or associated with
    hepatotoxic drugs
    • Adults : 1 tablet b.i.d. or 15 ml (tablespoonful) twice a day
    Children : 10 ml (2 teaspoonfuls) twice a day
In cases of
  • Jaundice(Kamala)
  • Hepatitis B infection
  • Liver cirrhosis(Halimaka)
    • Adults : 1 tablet t.i.d or 15 ml (tablespoonful) thrice a day
    Children : 10 ml (2 teaspoonfuls) thrice a day
Studies & Trial Reports