Dosage & Administration
Initial:
2 Tablet t.i.d. half an hour before food intake
Maintenance:
1 Tablet t.i.d. half an hour before meals

Precautions :
Supplements of fat-soluble vitamins & folic acid may be required

Side-effects :
Initial softening of stools, rarely diarrhoea or steatorrhoea which is self limiting.

Contraindication :
Complete biliary obstruction

Presentation
30 Tablets Blister / bottle

Composition
Tablets
Lophat tablets contains:
Guggula (Commiphora mukul) 50 mg
Psyllium (Plantago ovata) 150 mg
Lasuna (Allium sativum) 10 mg
Kutki (Picrorhiza kurroa) 10 mg
Amla (Emblica officinalis) 30 mg
References
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37 Sendl A, Elbl G, Steinke B, Redl K, Breu W, Wagner H. Comparative pharmacological investigations of Allium ursinum and Allium sativum. Planta Med. 1992; 58:1–7.
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39 Chang HS, Yamato O, Yamasaki M, Maede Y. Modulatory influence of sodium 2-propenyl thiosulfate from garlic on cyclooxygenase activity in canine platelets: Possible mechanism for the anti-aggregatory effect. Prostaglandins Leukot Essent Fatty Acids. 2005; 72:351–5.
40 Qi R, Liao F, Inoue K, Yatomi Y, Sato K, Ozaki Y. Inhibition by diallyl trisulfide, a garlic component, of intracellular Ca21 mobilization without affecting inositol-1,4,5-triphosphate (IP3) formation in activated platelets. Biochem Pharmacol. 2000;60:1475–83.
41 Tripathy SN, Shastri VVS, Satyavati GV. Experimental and clinical studies on the effect of guggulu (Commiphora mukul in hyperlipemia and thrombosis. J Res Indian Med 1968; 2:10.
42 Mester L, Mester M, Nityanand S. Inhibition of platelet aggregation by ‘‘guggulu’’ steroids. Planta Med 1979; 37(4):367-9.
43 Bordia A, Chuttani SK. Effect of gum guggulu on fibrinolysis and platelet adhesiveness in coronary heart disease. Indian J Med Res 1979; 70:992-6.
44 Baldwa VS, Sharma RC, Ranka PC. Effect of Commiphora mukul (guggul) on fibrinolytic activity and platelet aggregation in coronary artery disease. Rajas Med J 1980; 19(2):84-6.
45 Gaur SP, Garg RK, Kar AM. Gugulipid, a new hypolipidaemic agent, in patients of acute ischaemic stroke: effect on clinical outcome, platelet function and serum lipids. Asia Pacif J Pharm 1997; 12:65-9.
46 Moriguchi T, Takasugi N, Itakura Y. The effects of aged garlic extract on lipid peroxidation and the deformability of erythrocytes. J Nutr. 2001; 131: 1016S–9S.
47 Kempaiah RK, Srinivasan K. Influence of dietary spices on the fluidity of erythrocytes in hypercholesterolaemic rats. Br J Nutr. 2005; 93:81–91.
48 Kim-Park S, Ku DD. Garlic elicits a nitric oxide-dependent relaxation and inhibits hypoxic pulmonary vasoconstriction in rats. Clin Exp Pharmacol Physiol.2000; 27:780–6.
49  Sendl A, Elbl G, Steinke B, Redl K, Breu W, Wagner H. Comparative pharmacological investigations of Allium ursinum and Allium sativum. Planta Med. 1992; 58:1–7.
50 Yadav RK, Verma NS. Effects of garlic (Allium sativum) extract on the heart rate, rhythm and force of contraction in frog: a dose dependent study. Indian J Exp Biol. 2004; 42:628–31.
51 Ried K, Frank OR, Stocks NP, Fakler P, Sullivan T. Effect of garlic on blood pressure: A systematic review and meta-analysis. BMC Cardiovasc Disord. 2008 Jun 16; 8:13.
52 Bhattacharya A, Chatterjee A, Ghosal S, Bhattacharya S K. Antioxidant activity of active tannoid principles of Emblica officinalis (amla). Indian Journal of Experimental Biology 1999; 37: 676–680.
53 Bhattacharya S K, Bhattacharya A, Sairam K, Ghosal S. Effect of bioactive tannoid principles of Emblica officinalis on ischemia reperfusion- induced oxidative stress in rat heart. Phytomedicine 2002; 9: 171–174.
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55 Sairam M, Neetu D, Deepti P, Vandana M, Ilavazhagan G, Kumar D, Selvamurthy W. Cytoprotective activity of Amla (Emblica officinalis) against chromium (VI) induced oxidative injury in murine macrophages. Phytotherapy Research 2003;17: 430–433.
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67 Singh R B, Niaz M A, Ghosh S. Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia. Cardiovasc Drugs Ther
1994; 8:659-664.
68 Singh K, Chander R, Kapoor N K. Guggulsterone, a potent hypolipidaemic, prevents oxidation of low density lipoprotein. Phytother Res 1997; 11:291-294.
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Categories
Products
Lophat - tablets
Therapeutic Category : Lipid Lowering & Anti-obesity
Actions
The botanicals in Lophat tablets synergize to lower blood lipids by acting at two principle sites, namely, the intestines and the liver.

In the intestines, psyllium hydrophilic mucilloid and guggula-resins sequester bile acids and thereby reduce sequestration, micelle formation & absorption of dietary lipids.

In the liver, soluble psyllium fibers, Lasuna (allicin) and Amla impede hepatic lipid biosynthesis. Kutki, an established cholagogue, enhances diversion of hepatic cholesterol pool towards conversion to bile acids & enhances biliary excretion, which in turn being sequestered by psyllium hydrophilic mucilloid and guggula-resins in the intestines, are not re-absorbable in the colon are excreted through fecal excretion causing a net drain of cholesterol & lipids from systemic circulation.
Indications
  • Hypercholesterolemia
  • Hypertriglyceridaemia
  • Ischemic cardiac disease
  • Obesity (Medharoga)