Dosage & Administration
Initial:
2 Tablet t.i.d. half an hour before food intake
Maintenance:
1 Tablet t.i.d. half an hour before meals

Precautions :
Supplements of fat-soluble vitamins & folic acid may be required

Side-effects :
Initial softening of stools, rarely diarrhoea or steatorrhoea which is self limiting.

Contraindication :
Complete biliary obstruction

Presentation
30 Tablets Blister / bottle

Composition
Tablets
Lophat tablets contains:
Guggula (Commiphora mukul) 50 mg
Psyllium (Plantago ovata) 150 mg
Lasuna (Allium sativum) 10 mg
Kutki (Picrorhiza kurroa) 10 mg
Amla (Emblica officinalis) 30 mg
References
1. Stanley M, Paul D, Gacke D, et al. Effects of cholestyramine, Metamucil and cellulose on fecal bile salt excretion in man. Gastroenterology. 1973; 65:889–894.
2. Marlett JA & Fischer MH. A poorly fermented gel from psyllium seed husk increases excreta moisture and bile acid excretion in the rat. Journal of Nutrition. 2002; 132, 2638–2643.
3. Kritchevsky D, Story JA. Binding of bile salts in vitro by nonnutritive fiber. J Nutr 1974;104:458–62.
4. Mukherjee PK. Plant products with hypocholesterolemic potentials. Adv Food Nutr Res. 2003;47:277-338.
5. Gebhardt R. Multiple inhibitory effects of garlic extracts on cholesterol biosynthesis in hepatocytes. Lipids. 1993;28:613–9.
6. Liu L, Yeh YY. Water-soluble organosulfur compounds of garlic inhibit fatty acid and triglyceride synthesis in cultured rat hepatocytes. Lipids. 2001;36: 395–400.
7. Yeh YY, Liu L. Cholesterol-lowering effects of garlic extracts and organosulfur compounds: human and animal studies. J Nutr. 2001;131:989S–93S.
8. Yeh YY, Yeh SM. Garlic reduces plasma lipids by inhibiting hepatic cholesterol and triacylglycerol synthesis. Lipids. 1994;29:189–93.
9. Gupta N, Porter TD. Garlic and garlic derived compounds inhibit human squalene monooxygenase. J Nutr. 2001;131:1662–7.
10. Augusti KT, Chackery J, Jacob J, Kuriakose S, George S, Nair SS. Beneficial effects of a polar fraction of garlic (Allium sativum Linn) oil in rats fed with two different high fat diets. Indian J Exp Biol. 2005;43:76–83.
11. Chander R, Khama A K and Kapoor N K. Lipid Lowering Activity of Guggulsterone from Commiphora mukul in Hyperlipaemic Rats. Phytotherapy Research.1996; 10: 508-511.
12. Kapoor NK and Nityanand S: Effect of guggul steroids on cholesterol biosynthesis in rats. Ind J Biochem Biophy. 1978; 15: 77.
13. Singh V, Kaul S, Chander R, Kapoor NK. Stimulation of low density lipoprotein receptor activity in liver membrane of guggulsterone treated rats. Pharmacol Res. 1990; 22(1):37-44.
14. Urizar NL, Liverman AB, Dodds DT, Silva FV, Ordentlich P, Yan Y, Gonzalez FJ, Heyman RA, Mangelsdorf DJ, Moore DD (2002) A natural product that lowers cholesterol as an antagonist ligand for FXR. Science.296:1703-1706.
15. Wu J, Xia C, Meier J, Li S, Hu X, Lala DS (2002) The hypolipidemic natural product guggulsterone acts as an antagonist of the bile acid receptor. Mol Endocrinol 16:1590-1597.
16. Deng R. Therapeutic Effects of Guggul and Its Constituent Guggulsterone: Cardiovascular Benefits. Cardiovascular Drug Reviews.2007; 25(4): 375–390.
17. Ginter E. Ascorbic acid in cholesterol and bile acid metabolism. Ann N Y Acad Sci. 1975; 30(258): 410-21.
18. Hughes RE. Vitamin C and cholesterol metabolism. J Hum Nutr. 1976; 30(5):315-9.
19. Deng R,Yang D, RadkeA,Yang J,YanB(2007) The hypolipidemic agent guggulsterone regulates the expression of human bile salt export pump: Dominance of transactivation over farsenoid Xreceptormediated antagonism.J Pharmacol Exp Ther 320:1153-1162.
20. Sheela CG, Augusti KT. Effects of S-allyl cysteine sulfoxide isolated from Allium sativum Linn and gugulipid on some enzymes and fecal excretions of bile acids and sterols in cholesterol fed rats. Indian J Exp Biol 1995; 33(10):749-51.
21. Kumari K, Augusti KT (2007) Lipid lowering effect of S-methyl cysteine sulfoxide from Allium cepa Linn in high cholesterol diet fed rats. J Ethnopharmacol 109:367-371.
22. Shukla B, Visen PK, Patnaik GK, Dhawan BN. Choleretic effect of picroliv, the hepatoprotective principle of Picrorhiza kurroa. Planta Med. 1991; 57(1):29-33.
23. Kuppurajan K, Rajagopalan SS, Rao TK, Sitaraman R. Effect of guggulu (Commiphora mukul- Engl.) on serum lipids in obese subjects. J Res Indian Med 1973; 8(4):1-8.
24. Malhotra SC, Ahuja MM, Sundaram KR. Long term clinical studies on the hypolipidaemic effect of Commiphora mukul (Guggulu) and clofibrate. Indian J Med Res 1977; 65(3):390-5.
25. Kuppurajan K, Rajagopalan SS, Rao TK, Sitaraman R. Effect of guggulu (Commiphora mukul-Engl.) on serum lipids in obese, hypercholesterolemic and hyperlipemic cases. JAssoc Physicians India 1978; 26(5):367-73.
26. Gopal K, Saran RK, Nityanand S, Gupta PP, Hasan M, Das SK, et al. Clinical trial of ethyl acetate extract of gum gugulu (gugulipid) in primary hyperlipidemia. J Assoc Physicians India 1986; 34(4):249-51.
27. Agarwal RC, Singh SP, Saran RK, Das SK, Sinha N, Asthana OP, et al. Clinical trial of gugulipid—a new hypolipidemic agent of plant origin in primary hyperlipidemia. Indian J Med Res 1986; 84: 626-34.
28. Verma SK, Bordia A. Effect of Commiphora mukul (gum guggulu) in patients of hyperlipidemia with special reference to HDL-cholesterol. Indian J Med Res 1988; 87: 356-60.
29. Nityanand S, Srivastava JS, Asthana OP. Clinical trials with gugulipid. A new hypolipidaemic agent. J Assoc Physicians India 1989; 37(5):323-8.
30. Singh RB, Niaz MA, Ghosh S. Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia. Cardiovasc Drugs Ther
1994; 8(4):659-64.
31. Ghorai M, Mandal SC, Pal M, Pal SP, Saha BP. A comparative study on hypocholesterolaemic effect of allicin, whole germinated seeds of bengal gram and guggulipid of gum gugglu. Phytother Res 2000;14(3):200-2.m 2000; 8:2195-2209.
32 Adler A J, & Holub B J. Effect of garlic and fish-oil supplementation on serum lipid and lipoprotein concentrations in hypercholesterolemic men. American Journal of Clinical Nutrition,
1997; 65(2): 445-450.
33 Holzgartner H, Schmidt U & Kuhn U. Comparison of the efficacy and tolerance of a garlic preparation vs. Bezafibrate. Arzneimittelforschung, 1992; 42(12): 1473-1477.
34 Jain A K, Vargas R, Gotzkowsky S, & McMahon F G. Can garlic reduce levels of serum lipids? A controlled clinical study. The American Journal of Medicine, 1993; 94(6): 632-635.
35 Mader F H. Treatment of hyperlipidemia with garlic-powder tablets. Arznemittel Forschung, 1990; 40(10), 1111-1116.
36 Voberg G, & Schneider B. Therapy with garlic: Results of placebo-controlled, double-blind study. British Journal of Clinical Practice Supplement. 1990; 69: 7-11.
37 Sendl A, Elbl G, Steinke B, Redl K, Breu W, Wagner H. Comparative pharmacological investigations of Allium ursinum and Allium sativum. Planta Med. 1992; 58:1–7.
38 Teranishi K, Apitz-Castro R, Robson SC, Romano E, Cooper DK. Inhibition of baboon platelet aggregation in vitro and in vivo by the garlic derivative, ajoene. Xenotransplantation. 2003; 10:374–9.
39 Chang HS, Yamato O, Yamasaki M, Maede Y. Modulatory influence of sodium 2-propenyl thiosulfate from garlic on cyclooxygenase activity in canine platelets: Possible mechanism for the anti-aggregatory effect. Prostaglandins Leukot Essent Fatty Acids. 2005; 72:351–5.
40 Qi R, Liao F, Inoue K, Yatomi Y, Sato K, Ozaki Y. Inhibition by diallyl trisulfide, a garlic component, of intracellular Ca21 mobilization without affecting inositol-1,4,5-triphosphate (IP3) formation in activated platelets. Biochem Pharmacol. 2000;60:1475–83.
41 Tripathy SN, Shastri VVS, Satyavati GV. Experimental and clinical studies on the effect of guggulu (Commiphora mukul in hyperlipemia and thrombosis. J Res Indian Med 1968; 2:10.
42 Mester L, Mester M, Nityanand S. Inhibition of platelet aggregation by ‘‘guggulu’’ steroids. Planta Med 1979; 37(4):367-9.
43 Bordia A, Chuttani SK. Effect of gum guggulu on fibrinolysis and platelet adhesiveness in coronary heart disease. Indian J Med Res 1979; 70:992-6.
44 Baldwa VS, Sharma RC, Ranka PC. Effect of Commiphora mukul (guggul) on fibrinolytic activity and platelet aggregation in coronary artery disease. Rajas Med J 1980; 19(2):84-6.
45 Gaur SP, Garg RK, Kar AM. Gugulipid, a new hypolipidaemic agent, in patients of acute ischaemic stroke: effect on clinical outcome, platelet function and serum lipids. Asia Pacif J Pharm 1997; 12:65-9.
46 Moriguchi T, Takasugi N, Itakura Y. The effects of aged garlic extract on lipid peroxidation and the deformability of erythrocytes. J Nutr. 2001; 131: 1016S–9S.
47 Kempaiah RK, Srinivasan K. Influence of dietary spices on the fluidity of erythrocytes in hypercholesterolaemic rats. Br J Nutr. 2005; 93:81–91.
48 Kim-Park S, Ku DD. Garlic elicits a nitric oxide-dependent relaxation and inhibits hypoxic pulmonary vasoconstriction in rats. Clin Exp Pharmacol Physiol.2000; 27:780–6.
49  Sendl A, Elbl G, Steinke B, Redl K, Breu W, Wagner H. Comparative pharmacological investigations of Allium ursinum and Allium sativum. Planta Med. 1992; 58:1–7.
50 Yadav RK, Verma NS. Effects of garlic (Allium sativum) extract on the heart rate, rhythm and force of contraction in frog: a dose dependent study. Indian J Exp Biol. 2004; 42:628–31.
51 Ried K, Frank OR, Stocks NP, Fakler P, Sullivan T. Effect of garlic on blood pressure: A systematic review and meta-analysis. BMC Cardiovasc Disord. 2008 Jun 16; 8:13.
52 Bhattacharya A, Chatterjee A, Ghosal S, Bhattacharya S K. Antioxidant activity of active tannoid principles of Emblica officinalis (amla). Indian Journal of Experimental Biology 1999; 37: 676–680.
53 Bhattacharya S K, Bhattacharya A, Sairam K, Ghosal S. Effect of bioactive tannoid principles of Emblica officinalis on ischemia reperfusion- induced oxidative stress in rat heart. Phytomedicine 2002; 9: 171–174.
54 Sabu M C, Kuttan R. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. Journal of Ethnopharmacology 2002;81: 155–160.
55 Sairam M, Neetu D, Deepti P, Vandana M, Ilavazhagan G, Kumar D, Selvamurthy W. Cytoprotective activity of Amla (Emblica officinalis) against chromium (VI) induced oxidative injury in murine macrophages. Phytotherapy Research 2003;17: 430–433.
56 Chaudhuri R K. Emblica cascading antioxidant: a novel natural skin care ingredient. Skin Pharmacology and Applied Skin Physiology. 2002;15, 374–380.
57 Rajak S, Banerjee S K, Sood S, Dinda A K, Gupta Y K, Gupta S K, Maulik S K. Emblica officinalis causes myocardial adaptation and protects against oxidative stress in ischemic-reperfusion injury in rats. Phytotherapy Research 2004; 18, 54–60.
58 Verma PC, Basu V, Gupta V, Saxena G, Rahman LU. Pharmacology and Chemistry of a Potent Hepatoprotective Compound Picroliv Isolated from the Roots and Rhizomes of Picrorhiza kurroa Royleex Benth. (Kutki). Curr Pharm Biotechnol. 2009; 10(6):641-9.
59 Rajaprabhu, D., R. Rajesh, R. Jeyakumar, S. Buddhan, B. Ganesan and R. Anandan. Protective effect of Picrorhiza kurroa on antioxidant defense status in adriamycin-induced cardiomyopathy in rats. Journal of Medicinal Plants Research 2007; 1(4): 80-85.
60 Chander, R., Kapoor, N. K. and Dhawan, B. N., 1992, Picroliv, picroside-I and kutkoside from Picrorhiza kurroa are scavengers of superoxide anions. Biochem Pharmacol, 44: 180-183.
61 Russo, A., Izzo, A. A., Cardile, V., Borrelli, F. and Vanella, A.,, 2001, Indian medicinal plants as antiradicals and DNA cleavage protectors. Phytomedicine, 8(2): 125-132.
62 Singh, V., Visen, P. K., Patnaik, G. K., Kapoor, N. K. and Dhawan, B. N.. 1992, Effect of picroliv on low density lipoprotein receptor binding of rat hepatocytes in hepatic damage induced by paracetamol. Indian J Biochem Biophys., 29(5): 428-432.
63 Dillon SA, Burmi RS, Lowe GM, Billington D, Rahman K. Antioxidant properties of aged garlic extract: an in vitro study incorporating human low density protein. Life Sci. 2003;72:1583–94.
64 Dillon SA. Aged garlic extract as an antioxidant in cardiovascular disease [doctoral thesis]. Liverpool John Moores University, Liverpool, UK, 2002. pp 32–35. 28. Ide N, Lau BHS. Garlic compounds minimise intracellular oxidative stress and inhibit nuclear factor-kB activation. J Nutr. 2001;131:1020S–6S.
65 Geng Z, Lau BHS. Aged garlic extract modulates glutathione redox cycle and superoxide dismutase activity in vascular endothelial cells. Phytother Res. 1997;11:54–6.
66 Banerjee SK, Maulik SK. Effect of garlic on cardiovascular disorders: a review. Nutr J. 2002;1:4–14.
67 Singh R B, Niaz M A, Ghosh S. Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia. Cardiovasc Drugs Ther
1994; 8:659-664.
68 Singh K, Chander R, Kapoor N K. Guggulsterone, a potent hypolipidaemic, prevents oxidation of low density lipoprotein. Phytother Res 1997; 11:291-294.
69 Wang X, Greilberger J, Ledinski G, Kager G, Paigen B, J¨urgens G () The hypolipidemic natural product Commiphora mukul and its component guggulsterone inhibit oxidative modification of LDL. Atherosclerosis. 2004; 172:239-246.
70 Kaul S, Kapoor N K. Reversal of changes of lipid peroxide, xanthine oxidase and superoxide dismutase by cardio-protective drugs in isoproterenol induced myocardial necrosis in rats. Indian J Exp Biol 1989; 27: 625-627.
71 Chander R, Khanna AK, Pratap R. Antioxidant activity of guggulsterone, the active principal of guggulipid from Commiphora mukul. J Med Arom Plant Sci 2002; 24:370-374.
72 Batra S, Srivastava S, Singh K, Chander R, Khanna AK, Bhaduri A P. Syntheses and biological evaluation of 3-substituted amino-1-aryl-6-hydroxy-hex-2-ene-1-ones as antioxidant and hypolipidemic agents. Bioorg Med Chem 2000; 8:2195-2209.
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Categories
Products
Lophat - tablets
Therapeutic Category : Lipid Lowering & Anti-obesity
Actions
The botanicals in Lophat tablets synergize to lower blood lipids by acting at two principle sites, namely, the intestines and the liver.

In the intestines, psyllium hydrophilic mucilloid and guggula-resins sequester bile acids and thereby reduce sequestration, micelle formation & absorption of dietary lipids.

In the liver, soluble psyllium fibers, Lasuna (allicin) and Amla impede hepatic lipid biosynthesis. Kutki, an established cholagogue, enhances diversion of hepatic cholesterol pool towards conversion to bile acids & enhances biliary excretion, which in turn being sequestered by psyllium hydrophilic mucilloid and guggula-resins in the intestines, are not re-absorbable in the colon are excreted through fecal excretion causing a net drain of cholesterol & lipids from systemic circulation.
Indications
  • Hypercholesterolemia
  • Hypertriglyceridaemia
  • Ischemic cardiac disease
  • Obesity (Medharoga)