Dosage & Administration
Tablets:
1 tablet two times a day
Syrup:
10 ml two times a day

Presentation
Tablets:
30 tablets blister / bottle
Syrup:
100 ml & 200 ml bottle
Composition
Tablets
Each Nephroheal tablet contains:
Pashanbheda (Bergenia ligulata) 60 mg
Bhuiamla (Phyllanthus niruri) 60 mg
Varuna (Crataeva nurvala) 60 mg
Gokshru (Tribulus terrestris) 60 mg
Lajjalu (Mimosa pudica) 30 mg
Punarnava (Boerhaavia diffusa) 30 mg
Sudh Shilajeet (Purified Asphaltam) 10 mg
Syrup
Each 5 ml of Nephroheal syrup contains:
Pashanbheda (Bergenia ligulata) 100 mg
Bhuiamla (Phyllanthus niruri) 100 mg
Varuna (Crataeva nurvala) 100 mg
Gokshru (Tribulus terrestris) 50 mg
Lajjalu (Mimosa pudica) 50 mg
Punarnava (Boerhaavia diffusa) 50 mg
Sudh Shilajeet (Purified Asphaltam) 20 mg
References
1. S Bashir et al. Antiurolithic effect of Bergenia ligulata rhizome: An explanation of the underlying mechanisms Journal of Ethnopharmacology 122 (2009) 106–116
2. V.S. Joshi et al. Herbal extracts of Tribulus terrestris and Bergenia ligulata inhibit growth of calcium oxalate monohydrate crystals in vitro Journal of Crystal Growth 275 (2005) e1403–e1408
3. T. S. Garimella et al. In vitro Studies on Antilithiatic Activity of Seeds of Dolichos biflorus Linn. And Rhizomes of Bergenia ligulata Wall. Phytother. Res. (2001) 15, 351–355
4. M J. Joshi et al. Inhibition of the growth of urinary calcium hydrogen phosphate dihydrate crystals with aqueous extracts of Tribulus terrestris and Bergenia ligulata Urol Res (2005) 33: 80–86
5. A.Prathapan et al. Antiperoxidative, Free Radical Scavenging And Metal Chelating Activities Of Boerhaavia Diffusa. Journal Of Food Biochemistry 35 (2011) 1548–1554
6. B.Agarwal et al. Boerhaavia diffusa L - A Review on its Phytochemical and Pharmacological Profile. Asian J. Applied Sci., 2011 4(7): 663-684
7. S K. Pareta et al. Boerhaavia diffusa Linn Aqueous Extract As Curative Agent In Ethylene Glycol Induced Urolithiasis Pharmacologyonline (2010)3: 112-120
8. F Yasir et al. Effect of indigenous plant extracts on calcium oxalate crystallization having a role in urolithiasis Urol Res (2011) 39:345–350
9. C.K. Chauhan et al. Growth Inhibition of Struvite Crystals in the Presence of Herbal Extract Boerhaavia diffusa Linn. American Journal of Infectious Diseases 2009 5 (3): 170-179
10. G Chaudhary et al. Morphological, phytochemical and pharmacological, studies on Boerhaavia diffusa L. Journal of Medicinal Plants Research 4 June, 2011 Vol. 5(11), pp. 2125-2130
11. S. K. Pareta et al. Prophylactic Role of Boerhaavia diffusa in Ethylene Glycol Induced Calcium Oxalate Urolithiasis African Journal of Urology 2011 Vol. 17, No. 2, 28-36
12. T. Geetha et al. Anticomplement activity of triterpenes from Crataeva nurvala stem bark in adjuvant arthritis in rats General Pharmacology 32 (1999) 495–497
13. R. Anand et al. Antiurolithiatic Activity of Lupeol, the Active Constituent Isolated from Crateva nurvala. Phytotherapy Research, (1994) Vol 8,417-421
14. L. Vidya et al. Control of urinary risk factors of stones by betulin and lupeol in experimental hyperoxaluria Fitoterapia (2000) 71 535-543
15. P. Varalakshmi et al. Effect Of Crataeva Nurvala In Experimental Urolithiasis Journal of Elhnopharmacology, 28 (1990) 313- 321
16. P. Varalakshmi et al. Effect of Crataeva Nurvala on the Biochemistry of the Small Intestinal Tract of Normal and Stone forming Rats Journal of Ethnopharmacology, 31(1991) 67-73
17. P P Singh et al Effect of simultaneous sodium oxalate and methionine feeding with and without Varuna (Crataeva Nurvala Hook & Frost) therapy on urolithogenesis in guinea pigs. Indian Journal of Clinical Biochemistry, 1992, 7, 23-26
18. T. Geetha et al . Effect Of Triterpenes From Crataeva Nurvala Stem Bark On Lipid Peroxidation In Adjuvant Induced Arthritis In Rats Pharmacological Research, Vol. 37, No. 3, 1998
19. R. Baskar et al. Effect Of Crataeva Nurvala Bark Decoction On Enzymatic Changes In Liver Of Normal And Stone Forming Rats. Indian Journal Of Clinical Biochemistry, 1995, 10 (2), 98-102
20. A Shirwaikar et al Ethanol Extract of Crataeva nurvala Stem Bark Reverses Cisplatin-induced Nephrotoxicity Pharmaceutical Biology 2004, Vol. 42, No. 7, pp. 559–564
21. M.M. Malini et al. Protective Effect Of Triterpenes On Calcium Oxalate Crystal-Induced Peroxidative Changes In Experimental Urolithiasis Pharmacological Research, 2000 Vol. 41, No. 4
22. S Agarwal et al. Urolithic property of Varuna (Crataeva nurvala): An experimental study Ayu. 2010 Jul-Sep; 31(3): 361–366.
23. R Laikangbam et al. Anti-bacterial efficacy of elite medicinal plants on urolithiasis inducing flora. Journal of Food, Agriculture & Environment 2009 Vol.7(2):40- 45.
24. Tultul Koksi Sangma, et al. Diuretic property of aqueous extract of leaves of Mimosa pudica Linn. on experimental albino rats. Journal of Natural Products, 2010, 3:172-178
25. V Goli et al Effects of Anti-Inflammatory Activity of Mimosa pudica. Asian J. Pharm. Res. 2011; Vol. 1: Issue 3, Pg 69-71
26. D D. Kokane et al. Evaluation of wound healing activity of root of Mimosa pudica Journal of Ethnopharmacology 124 (2009) 311–315
27. A Tiwari et al. An Overview On Potent Indigenous Herbs For Urinary Tract Infirmity: Urolithiasis. Asian J Pharm Clin Res, 2012 Vol 5, Suppl 1, 7-12
28. Singh et al. Wound Healing Potential of Alcoholic Extract of Mimosa pudica Linn. Leaves. Pharmacologyonline 2: 32-38 (2010)
29. M E.Barros et al. Effect of extract of Phyllanthus niruri on crystal deposition in experimental urolithiasis Urol Res (2006) 34:351–357
30. M.E. Barros et al. Effects of an aqueous extract from Phyllanthus niruri on calcium oxalate crystallization in vitro Urol Res (2003) 30:374–379
31. S Woottisin et al. Effects of Orthosiphon grandiflorus, Hibiscus sabdariffa and Phyllanthus amarus Extracts on Risk Factors for Urinary Calcium Oxalate Stones in Rats The Journal of Urology January 2011 Vol. 185, 323-3
32 G.A. Asare et al. Genotoxicity, cytotoxicity and toxicological evaluation of whole plant extracts of the medicinal plant Phyllanthus niruri (Phyllanthaceae) Genetics and Molecular Research 11 (1): 100-111 (2012)
33 C.I. Wright et al. Review Herbal medicines as diuretics: A review of the scientific evidence Journal of Ethnopharmacology 114 (2007) 1–31
34 V. Murugaiyah, K.-L. Chan Mechanisms of antihyperuricemic effect of Phyllanthus niruri and its lignan constituents Journal of Ethnopharmacology 124 (2009) 233–239
35 M. A. Boim et al Phyllanthus niruri as a Promising Alternative Treatment for Nephrolithiasis International Braz J Urol November - December, 2010 Vol. 36 (6): 657-664
36 Alexandre H. Campos Phyllanthus niruri Inhibits Calcium Oxalate Endocytosis by Renal Tubular Cells: Its Role in Urolithiasis Nephron 1999; 81:393–397
37 J. L. Nishiura et al. Phyllanthus niruri normalizes elevated urinary calcium levels in calcium stone forming (CSF) patients Urol Res (2004) 32: 362–366
38 G. Bagalkotkar et al. Phytochemicals from Phyllanthus niruri Linn. and their Pharmacological properties: a review JPP 2006, 58: 1559–1570
39 A A Adeneye et al. Protective effect of the aqueous leaf and seed extract of Phyllanthus amarus on gentamicin and acetaminophen-induced nephrotoxic rats Journal of Ethnopharmacology 118 (2008) 318–323
40 A.M. Freitas et al. The effect of Phyllanthus niruri on urinary inhibitors of calcium oxalate crystallization and other factors associated with renal stone formation BJU International (2002), 89, 829–834
41 M.D. Ukani et al A Review On The Ayurvedic Herb Tribulus Terrestris L. Ancient Science of Life Vol No. 17 (2), October 1997 pages 144 - 150
42 V Arasaratnam et al. A study of Tribulus terrestris extract on risk factors for urinary stone in normal subjects and urolithic patients. J.Natn.Sci.Foundation Sri Lanka 2010 38 (3):187-191
43 Aggarwal et al. Diminution of Oxalate Induced Renal Tubular Epithelial Cell Injury and Inhibition of Calcium Oxalate Crystallization in vitro by Aqueous Extract of Tribulus terrestris Int Braz J Urol. 2010; 36: 480-9
44 Kamboj P et al. Effect of aqueous extract of Tribulus terrestris on oxalate-induced oxidative stress in rats. Indian J Nephrol. 2011 Jul;21(3):154-9.
45 D. Sangeetaa et al. Effect of Tribulus terrestris on oxalate metabolism in rats Journal of Ethnopharmacology 44 (1994) 61-66
46 Vimal S. Joshi et al. Inhibition of the growth of urinary calcium hydrogen phosphate dihydrate crystals with aqueous extracts of Tribulus terrestris and Bergenia ligulata Urol Res (2005) 33: 80–86
47 Shaheen G et al. Review Monograph of Tribulus terrestris. J Med Plants Res, 2012, Vol. 6(5), pp. 641-644.
48 D. Sangeeta et al. Therapeutic response of Tribulus terrestris (Gokhru) aqueous extract on hyperoxaluria in male adult rats. Phytotherapy Research, Vol. 7, 116-119 (1993)
49 M Ali et al. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays Journal of Ethnopharmacology 85 (2003) 257–260
50 Ruchi Pandey et al. Tribulus terrestris fruit extract protects against oxidative stress-induced apoptosis. Pharmaceutical Biology 2007, Vol. 45, No. 8, pp. 619–625
51 M. Akram et al. Tribulus terrestris Linn.: A review article. J Med Plants Res, 2011, Vol. 5(16), pp. 3601-3605.
52 Anand Tiwari et al. An Overview On Potent Indigenous Herbs For Urinary Tract Infirmity: Urolithiasis Asian J Pharm Clin Res, 2012Vol 5, Suppl 1, 7-12
53 S Kieley et al. Ayurvedic Medicine and Renal Calculi JOURNAL OF ENDOUROLOGY August 2008 Volume 22, Number 8
54 Butterweck V, Khan SR. Herbal medicines in the management of urolithiasis: alternative or complementary? Planta Med 2009; 75: 1095–1103
55 H R. Chitme et al. Herbal treatment for urinary stones IJPSR. 2010, 1(2): 24-31
Explore Product
Categories
Products
Nephroheal Tablets & Syrup
Therapeutic Category : Litholytic Nephroprotective Diuretic
Actions
Multiple botanicals in Nephroheal tablets & syrup synergise to exhibit diuretic, litholytic and nephro-protective action which :
  • Facilitates removal of existing calculi by
    o Detaching crystals attached to cell surface
    o Dissolution & disintegration of crystals
    o Flushing of crystals due to diuresis
  • Reduces recurrence of new calculi by
    o Decreasing new matrix calculi growth, crystal growth and aggregation Increasing incorporation of endogenous inhibitors of renal calculi formation, namely, glycosaminoglycans (GAGs) into calculi, making them softer
    o Decreasing urinary oxalate excretion
    o Decreasing calcium phosphate precipitation
  • Protects nephrons by
    o Anti-oxidant & rejuvenative activity
    o Augmenting local host immune responses
    o Reducing recurrent UTIs
Use
  • Urinary disorders (Mutraroga)
  • Dysuria (Mutrakrcchra)
  • Kidney stones / Urinary calculus (Mutrasarkara)
  • Burning micturation (Mutradaha)
  • Oligouria (Mutrasada)
  • Renal / Ureteric colic (Pratuni)