Description
This specialised Food for Special Medical Purposes (FSMP) is designed to address the core pathophysiological mechanisms of Sickle Cell Disease, including oxidative stress, red blood cell adhesion, endothelial dysfunction, and chronic micronutrient deficiencies.
The formulation delivers clinically validated amino acids (L-Glutamine and L-Arginine) along with essential vitamins and minerals to reduce vaso-occlusive episodes, improve microvascular blood flow, and strengthen overall nutritional status. It provides a convenient, home-based nutritional intervention that supports long-term disease management and reduces hospital dependence.
Key Benefits
- Reduces Vaso-Occlusive Crisis (VOC) Frequency
- L-Glutamine increases intracellular antioxidant capacity
- Significantly decreases painful crises and hospitalisations
- Reduces oxidative stress that triggers red blood cell sickling
- Improves Blood Flow & Tissue Oxygenation
- L-Arginine enhances nitric oxide bioavailability
- Reduces red blood cell adhesion to blood vessel walls
- Improves microvascular circulation and tissue perfusion
- Accelerates Wound & Ulcer Healing
- Zinc supports tissue regeneration and repair
- Particularly beneficial for chronic leg ulcers in SCD patients
- Strengthens Overall Nutritional Status
- Corrects common deficiencies in vitamins A, C, D, E, folic acid, magnesium, and calcium
- Supports immune function, energy levels, and quality of life
- Addresses elevated nutritional needs of chronic haemolytic anaemia
- Convenient Home-Based Management
- Single-dose sachets with no refrigeration required
- Improves treatment adherence
- Enables consistent nutritional therapy without cold-chain logistics
Key Ingredients
- L-Glutamine (US FDA Approved)
- Increases antioxidant production in sickle red blood cells
- Neutralises oxidative stress that promotes sickling and VOCs
- L-Arginine
- Substrate for nitric oxide synthesis
- Improves endothelial function and vascular dilation
- Reduces pathological cell adhesion
- Folic Acid + Essential Vitamins & Minerals
- Supports erythrocyte maturation
- Addresses increased nutritional demands of chronic haemolysis
- Zinc promotes wound healing and tissue repair
Usage & Dosage
- Children (2–9 years):
- 15 g (one sachet) twice daily
- Adolescents (10–18 years):
- 30 g (two sachets) twice daily
- Adults (above 18 years):
- Body weight <30 kg: 15 g twice daily
- Body weight 30–65 kg: 30 g twice daily
- Body weight >65 kg: 30 g three times daily
Directions for Use
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Dissolve 15 g (one sachet) in 75 ml of freshly boiled and cooled water
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OR dissolve 30 g (two sachets) in 150 ml of freshly boiled and cooled water
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Stir well and consume immediately
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Forms a palatable therapeutic beverage
Understanding Vaso-Occlusive Crises (VOCs)
Vaso-occlusive crises are the most common acute complication of Sickle Cell Disease and the leading cause of emergency visits and hospitalisation. These episodes occur when rigid, sickled red blood cells block small blood vessels, causing tissue ischemia, severe pain, and potential organ damage.
The underlying mechanisms include:
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Haemoglobin S polymerisation
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Increased red blood cell adhesion
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Endothelial dysfunction
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Inflammation and oxidative stress
This formulation directly targets these mechanisms to break the vicious cycle of vascular obstruction and tissue injury.
Strategic Value for Government & Public Health Programs
- Reduces Hospitalisation Costs
- Lowers frequency and severity of VOCs
- Decreases emergency admissions and inpatient care expenditure
- Optimises Critical Care Resources
- Prevents severe complications such as VOCs and acute chest syndrome
- Frees ICU beds, emergency capacity, and specialist resources
- Enables Sustainable Disease Management
- No refrigeration required for sachets
- Facilitates large-scale home-based care
- Prevents chronic complications such as leg ulcers and recurrent infections
- Supports cost-effective implementation in programs like the National Sickle Cell Anaemia Elimination Mission
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